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Meta-analysis of cross-over trials.

Heather O. Dickinson.
Gynaecological Cancer Group.
Marta Roqué i Figuls.
Iberoamerican Cochrane Centre.

heather.dickinson doesnotexist@cochrane.org ncl.ac.uk


Objective: To provide review authors with the knowledge and skills that they need to abstract data from reports of cross-over trials and include such data in a meta-analysis.

Summary: The workshop will discuss randomized controlled trials with a two-period, two-treatment cross-over design such that each participant in the trial receives both treatments. It will focus primarily on continuous outcomes and will cover:

• What is a cross-over trial;
• Why include cross-over trials in a meta-analysis;
• Problems with cross-over trials;
• Combining parallel and cross-over trials in a meta-analysis;
• Carry over effects;
• Practical issues of data abstraction for cross-over trials.