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Systematic reviews of diagnostic test accuracy studies. 5: Applying the results in clinical practice.

Agostino Colli, Piergiorgio Duca, Giovanni Casazza, Mirella Fraquelli, Miriam Brazzelli and Dario Conte.
Cochrane Screening and Diagnostic Tests Methods Group.

a.colli doesnotexist@cochrane.org ospedale.lecco.it

Objectives:

• To provide information on how evidence from diagnostic systematic reviews can be used in clinical practice;
• To decide which information relevant to clinical decision making should be included in a diagnostic systematic review.

• The rationale of diagnostic decision-making, including test-no treatment and test-treatment;
• Thresholds;
• The use of measures of diagnostic test accuracy (e.g. sensitivity, specificity, likelihood ratios) in clinical practice;
• The influence of the pre-test probability on test results;
• Additional factors which may influence test results.

• A brief introduction about interpretation of diagnostic test results;
• A discussion on how diagnostic test results can influence clinical decision-making;
• Practical exercises to illustrate the concepts of diagnostic decision-making.

• Researchers and clinicians interested in conducting diagnostic test accuracy systematic reviews;
• Clinicians and policy makers interested in learning about the implications of applying results of diagnostic test accuracy systematic reviews to clinical practice.